Encapsulation of (E)-N’-(1-(7-(diethylamino)-2-oxo-2H-chromen-3 yl)ethylidene)benzohydrazide (7-diEAHC) in β-cyclodextrins: Optimized synthesis of 7-diEACH and in silico ADME profiling, physical stability, antioxidant properties of encapsulated 7-diEAHC and bioavailability in rats

The β-cyclodextrins (β-CD) as supramolecular have extremely attractive pharmaceutical applications. This study focused on the effects of macrocyclic systems complexation stability, antioxidant activities, and bioavailability optimized synthesis coumarin incorporating hydrazone moiety. Optimal (E)-N’-(1-(7-(diethylamino)-2-oxo-2H-chromen-3-yl)ethylidene)benzohydrazide (7-diEAHC) was performed by using response surface methodology (RSM) with a temperature 100 °C, reaction time 10 min in presence acetic acid (0.85 M). Physicochemical properties silico ADME profiling 7-diEAHC were also determined. encapsulation efficiencies above 81 % for micro-encapsulates. After sunlight exposure, 7-diEAHC-β-CD inclusion complex showed photostability 19.4 higher than free 7-diEAHC. Additionally, encapsulated exhibited better stability pH varied between 1 9. From results, storage that method β-CD conferred greater ability against temperature. NMR FT-IR techniques employed to evaluate chemical after encapsulation. In addition, vivo micro-encapsulation approach increased oral treated rats.